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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Multiple isomorphous replacement ： ウィキペディア英語版 Multiple isomorphous replacement Multiple isomorphous replacement or MIR is, historically speaking, the most common approach to solving the phase problem in X-ray crystallography. This method is conducted by soaking the crystal of a sample to be analyzed with a heavy atom solution or co-crystallization with the heavy atom. The addition of the heavy atom should not affect the crystal formation or unit cell dimensions in comparison to its native form, hence, they should be isomorphic. Data sets from the native and heavy-atom derivative of the sample are first collected. Then the interpretation of the Patterson difference map reveals the heavy atom's location in the unit cell. This allows both the amplitude and the phase of the atom to be determined. Since the structure factor of the heavy atom derivative (Fph) of the crystal is the vector sum of the lone heavy atom (Fh) and the native crystal (Fp) then the phase of the native Fp and Fph vectors can be solved geometrically. :$\backslash mathbf\; F\_\; =\; \backslash mathbf\; F\_p\; +\; \backslash mathbf\; F\_h$ At least two isomorphous derivatives must be evaluated since using only one will give two possible phases. ==Examples== Some examples of heavy atoms used in protein MIR: *Hg2+ ions bind to thiol groups. *Uranyl salts (UO2 + NO3) bind between carboxyl groups in Asp and Glu *Lead binds to Cys residues. *PtCl42− (ion) bind to His 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Multiple isomorphous replacement」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.